I installed Diablo II and LoD via wine. Video test app (on D2 disc/install) reports only DirectDraw as an option. Direct rendering is working, using latest nvidia drivers in sabayon repo. I'm not sure where to begin with this. I guess when my patience resumes I can try installing it against the Live DVD. I tried it in (K)ubuntu 8.04 updated fully which gives wine 1.0.1, iirc, and it works just fine without any configuration.
Edit: 3.5 x86_64 release fully updated, wine version is 1.1.5