Okay then it could be the iso file is incomplete or the burning process messed the actual info on the dvd disk up . Weard that it works in virtualbox. Try booting from the dvd + virtualbox and not the iso image.
Sabayon might not like the pc / usb dvd combo ? sry but anything is possible.
Nero has caused a lot of bugs and is being fixed , also if downloaded by ftp , 2 iso files I have found recently was only 99% complete on different servers we are fixing this as well.
ie: if torrent azureus has a force recheck option and ftp programs some has a hash check = same thing as md5sum check. Might not be this at all but worth a test.
This is the only things I can think of as possibly causing a bug like that.
It could be something totally different.
Usb emulation has to be enabled on some pc's to help usb device to boot. You do not have a F12 or F8 option during bios load that can be pressed and then shows bootable devices then select the usb dvd and hopefully it would let the dvd spin up and load.
Do you have any other bootable dvd's you can try maybe something is blocking the dvd part of the usb dvd drive from booting or needs a special driver but allows bootable cd's to work.
Something silly I did once = put the iso file onto the dvd instead of using the iso and burning the iso contents to a dvd LOL
This is all I can think of for now.